Type I Interferon Response Is Delayed in Human Astrovirus Infections

Type I Interferon Response Is Delayed in Human Astrovirus Infections

Type I interferon (IFN) activation and its subsequent effects are important in the response to viral infections. Here we show that human astroviruses (HAstVs), which are important agents of acute gastroenteritis in children, induce a mild and delayed IFN response upon infecting CaCo-2 cells. Although IFN-β mRNA is detected within infected cells and supernatant from infected cells show antiviral...

ULK1 in type I interferon response

Type I interferon (IFN) signaling leads to transcription and translation of key IFN-stimulated genes (ISGs), whose protein products exhibit anti-tumorigenic, anti-viral, and immunomodulatory functions [1-3]. These responses are triggered by the interaction of type I IFNs (IFNα, IFNβ, IFNω) with a unique cell surface receptor composed by two subunits: IFNα receptor 1 (IFNAR1) and IFNAR2 [1-3]. A...

Activation of the Type I Interferon Pathway Is Enhanced in Response to Human Neuronal Differentiation

Despite the crucial role of innate immunity in preventing or controlling pathogen-induced damage in most, if not all, cell types, very little is known about the activity of this essential defense system in central nervous system neurons, especially in humans. In this report we use both an established neuronal cell line model and an embryonic stem cell-based system to examine human neuronal inna...

Human T Lymphotropic Virus Type I (HTLV-I) is a Risk Factor for Coronary Artery Disease

Type I Interferon in Human Autoimmunity

The type I interferon system plays a critical role in host defense in health, and a growing body of literature suggests that type I interferon is a critical mediator of human autoimmune disease (1). Type I interferons function as a bridge between the innate and adaptive immune systems, and as such play an important role in setting thresholds for response against self antigens. Many investigator...